Tirzepatide vs Retatrutide
Both are highly effective GLP-1 medications. Here's how they compare to help you make the right choice.
Not sure? Take the quiz →Tirzepatide
Proven & Affordable
The go-to choice for most people. FDA approved, extensively studied, and our most affordable option.
- Best for first-timers
- More safety data available
- Lower starting cost
From ₱4,500/month
Learn More →Retatrutide
Maximum Results
The next generation. Triple mechanism for those who want the best possible results or have plateaued on other medications.
- Highest efficacy in trials
- Best for plateaus
- Exclusive in PH
From ₱6,500/month
Learn More →Detailed Comparison
| Feature | Tirzepatide | Retatrutide |
|---|---|---|
| Mechanism | Dual agonist (GLP-1 + GIP) | Triple agonist (GLP-1 + GIP + Glucagon) ✓ |
| Avg. Weight Loss | 15-21% | 17-24% ✓ |
| Trial Duration | 72 weeks ✓ | 48 weeks |
| FDA Status | Approved (2022) ✓ | Phase 3 trials |
| Starting Price | ₱4,500/month ✓ | ₱6,500/month |
| Dosing | Once weekly | Once weekly |
| Safety Data | Extensive (millions of users) ✓ | Limited (trial participants) |
| PH Availability | Multiple providers | MetabolixPH exclusive ✓ |
Which Is Right for You?
Choose Tirzepatide if you:
- Are new to GLP-1 medications
- Prefer medications with extensive long-term data
- Want an affordable entry point
- Have moderate weight loss goals (10-20%)
- Prefer a steady, gradual approach
Choose Retatrutide if you:
- Want maximum possible results
- Have plateaued on other GLP-1s
- Have significant weight to lose (20+ kg)
- Want results as fast as safely possible
- Budget is flexible for best results
The Science Explained
Why Does Mechanism Matter?
GLP-1, GIP, and Glucagon are hormones that regulate appetite, blood sugar, and energy expenditure. More receptors targeted = more pathways to weight loss. Retatrutide's additional glucagon activity is thought to increase calorie burning, which may explain its superior results in trials.
Clinical Trial Comparison
Tirzepatide (SURMOUNT-1)
20.9%
weight loss at 72 weeks
Retatrutide (Phase 2)
24.2%
weight loss at 48 weeks
Note: Different trial durations make direct comparison imperfect. Phase 3 results for Retatrutide expected in 2025.
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