MOTS-c

MOTS-c is one of the most exciting discoveries in metabolic research. Unlike most peptides that are encoded in nuclear DNA, MOTS-c is encoded in mitochondrial DNA—making it part of a special class of signaling molecules called mitochondrial-derived peptides (MDPs).

The AMPK Connection

The key to MOTS-c's effects is its ability to activate AMPK (AMP-activated protein kinase). AMPK is often called the body's "metabolic master switch" because it:

• Increases glucose uptake into cells
• Stimulates fatty acid oxidation (fat burning)
• Inhibits fat and cholesterol synthesis
• Promotes mitochondrial biogenesis (new mitochondria)

Exercise Mimetic Effects

AMPK is naturally activated by exercise. By activating AMPK, MOTS-c produces some of the same metabolic benefits as physical activity:

• Improved insulin sensitivity
• Better glucose tolerance
• Enhanced fat metabolism
• Increased cellular energy

This doesn't mean MOTS-c replaces exercise—physical activity has benefits that go far beyond AMPK activation. Instead, MOTS-c can be viewed as a tool to support metabolic health, especially in those who may have difficulty exercising or who want to optimize their results.

Age-Related Decline

Research shows that MOTS-c levels decline with age, which may contribute to age-related metabolic dysfunction. Supplementing MOTS-c could help restore youthful metabolic function.